Naslov
COMPREHENSIVE ESI MS AND MS/MS ANALYSIS OF AROMATIC HYDRAZONES DERIVED FROM NICOTINIC ACID HYDRAZIDE

Autori
Stražić, Dubravka ; Benković, Tomislav ; Kontrec, Darko ; Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
5th EuCheMS 2014 Chemistry Congress Book of Abstract / - Istanbul, 2014, 1316-1316

Skup
5th EuCheMS 2014 Chemistry Congress

Mjesto i datum
Istanbul, Turska, 31.08.2014. - 04.09.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
aromatic hydrazones; tandem mass spectrometry

Sažetak
Aroylhydrazones 1-13 derived from nicotinic acid hydrazide and differently substituted benzaldehyde or ketone (2-hydroxyacetophenone and 2-hydroxybenzophenone) were analyzed by ESI MS both in positive and negative ion mode. The influence of the solvent (acetonitrile, methanol, addition of sodium acetate) on signal intensities was investigated. A comprehensive study of fragmentation pathways of hydrazones using triple quadrupole instrument is presented. Structural isomers of aroylhydrazones were distinguished by tandem mass spectrometry. Compounds 3 and 4 (derived from 3- and 4-hydroxy salicylaldehyde) as well as 8 and 9 (derived from 3- and 5-chloro salicylaldehyde) were distinguished by MS/MS as a result of ortho effect. The MS/MS spectra and fragmentation pathways of compounds 6 and 7 (derived from 3- and 4-methoxy salicylaldehyde, respectively) differ due to enolimino-ketoamino tautomeric interconversion of 6. Homolytic cleavage and formation of radical cation was observed for compound 11, bearing nitro group in meta position with respect to C=N double bond.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA