Pregled bibliografske jedinice broj: 715628
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel
Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel // FEBS letters, 585 (2011), 2; 328-334 doi:10.1016/j.febslet.2010.12.008 (međunarodna recenzija, kratko priopcenje, znanstveni)
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Naslov
Biphasic effect of nitric oxide on the cardiac
voltage-dependent anion channel
Autori
Cheng, Q. ; Sedlić, Filip ; Pravdić, Danije ; Bosnjak, Željko J. ; Kwok, W.M.
Izvornik
FEBS letters (0014-5793) 585
(2011), 2;
328-334
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
nitric oxide ; voltage dependent anion channel ; lipid bilayer ; mitochondrial permeability transition pore
Sažetak
Nitric oxide (NO·) effects on the cardiac mitochondrial voltage-dependent anion channel (VDAC) are unknown. The effects of exogenous NO· on VDAC purified from rat hearts were investigated in this study. When incorporated into lipid bilayers, VDAC was inhibited directly by an NO· donor, PAPA NONOate, in a concentration-dependent biphasic manner. This was prevented by an NO· scavenger, 2-phenyl-4, 4, 5, 5- tetramethylimidazoline-1-oxyl-3-oxide. The effect paralleled that of NO() in delaying the opening of the mitochondrial permeability transition (PT) pore. These biphasic effects on the cardiac VDAC and the mitochondrial PT pore reveal a tandem impact of NO() on the two mitochondrial entities.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
