Naslov
Anxious depression and the stiff-person plus syndrome

Autori
Čulav-Sumić, Jadranka ; Bošnjak, Ivan ; Paštar, Zvonimir ; Jukić, Vlado

Izvornik
Cognitive and behavioral neurology (1543-3633) 21 (2008), 3; 242-245

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, ostalo, stručni

Ključne riječi
anxious depression; stiff-person plus syndrome

Sažetak
OBJECTIVE: To present the case of a patient with anxiety and depressive symptoms who developed the clinical picture of stiff-person plus syndrome (SPS-plus). BACKGROUND: Before the onset of typical SPS symptoms, psychiatric symptoms (like depression and anxiety) may be prominent and as such misleading, resulting in the diagnosis of a psychiatric condition. METHOD: We describe the case of a woman who initially presented with anxious depression and remained resistant to treatment with different classes of antidepressants and additional therapy with lithium and atypical antipsychotics. RESULTS: Evidence of neurologic dysfunction and significantly increased levels of serum autoantibodies for glutamic acid decarboxylase supported the diagnosis of SPS. The patient appeared to benefit from short-term immunosuppressive therapy with methylprednisolone. CONCLUSIONS: The authors believe that anxious depression and SPS-plus seen in this patient are the result of the same underlying autoimmune process, together forming a unique syndrome. Anxious and depressive symptoms in SPS can be explained by alterations in GABAergic neurotransmission.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA