Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances

Kao, A.C.C.; Rojnić Kuzman, Martina; Tiwari, A.K.; Živković, M.V.; Chowdhury, N.I.; Medved, Vesna; Kekin, Ivana; Zai, C.C.; Lieberman, J.A.; Meltzer, H.Y.; Bozina, Tamara; Božina, Nada; Kennedy, J.L.; Sertić, Jadranka; Müller, D.J.

doi:10.1016/j.jpsychires.2014.03.012

Pregled bibliografske jedinice broj: 713709

Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances

Kao, A.C.C.; Rojnić Kuzman, Martina; Tiwari, A.K.; Živković, M.V.; Chowdhury, N.I.; Medved, Vesna; Kekin, Ivana; Zai, C.C.; Lieberman, J.A.; Meltzer, H.Y. et al.

Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances // Journal of psychiatric research, 54 (2014), 36-42 doi:10.1016/j.jpsychires.2014.03.012 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 713709 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Methylenetetrahydrofolate reductase gene variants and antipsychotic-induced weight gain and metabolic disturbances

Autori
Kao, A.C.C. ; Rojnić Kuzman, Martina ; Tiwari, A.K. ; Živković, M.V. ; Chowdhury, N.I. ; Medved, Vesna ; Kekin, Ivana ; Zai, C.C. ; Lieberman, J.A. ; Meltzer, H.Y. ; Bozina, Tamara ; Božina, Nada ; Kennedy, J.L. ; Sertić, Jadranka ; Müller, D.J.

Izvornik
Journal of psychiatric research (0022-3956) 54 (2014); 36-42

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
A1298C; Antipsychotic; C677T; MTHFR; Weight gain

Sažetak
Weight gain and metabolic disturbances represent serious side-effects in antipsychotic (AP) treatment, particularly with clozapine and olanzapine. The methylenetetrahydrofolate reductase (MTHFR) gene is a key determinant in the folate metabolism and previous studies reported a significant effect on AP-induced weight gain and related metabolic abnormalities. Thus, we investigated MTHFR gene variants and changes in several important metabolic parameters in AP-treated patients. In this study, two functional MTHFR polymorphisms, rs1801133 (C677T) and rs1801131 (A1298C), were investigated for changes in weight and metabolic parameters. Genotypic associations were evaluated in a large population (n = 347 including 66 first episode psychosis, FEP patients) treated mostly with clozapine and olanzapine. We did not detect any genotypic association with weight changes (p > 0.05) in our total sample and in the sample refined for ancestry and medication. In our allelic analyses, we observed a trend for the 677-C allele to be associated with weight gain in the total sample (p = 0.03). This effect appeared to be driven by the FEP patients where those carrying the C-allele gained, on average, twice as much weight. Exploratory analyses revealed a significant association between the C677T and the A1298C polymorphism with HDL cholesterol serum levels in patients (p = 0.031). Overall we did not detect a major effect of two functional MTHFR gene variants and AP-induced weight gain. However, our findings suggest an effect of the C677T polymorphism in FEP patients and changes in weight and cholesterol levels. Further investigations in a larger sample are required.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Ustanove:
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Profili:

Martina Rojnić Kuzman (autor)