Naslov
Observational study of patients switched to the fixed combination travoprost 0, 004%/timolol 0, 5%

Autori
Mandić, Zdravko ; Novak-Lauš, Katja ; Bojić, Lovro ; Popović-Suić, Smiljka ; Ekert, Miroslav ; Maričić Došen, Vukosava ; Clementi, Damira ; Pelčić, Goran ; Dobutović, Davor ; Biuk, Dubravka ; Zorić-Geber, Mia ; Kovačić, Željko ; Pavan, Josip ; Kapeli-Dogan, Katarina ; Kovačević, Suzana ; Tomić, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
European Journal of Ophthalmology 2009 ; 19 (suppl. 1) EP-GL-335 / - , 2009

Skup
The 17th Congress of the European Society of Ophthalmology

Mjesto i datum
Amsterdam, Nizozemska, 13.06.2009. - 16.06.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
primary open angle glaucoma; ocular hypoertension; fixed combination antiglaucoma treatment

Sažetak
Purpose: To assess the safety and efficacy of changing antiglaucoma therapy to the travoprost 0, 004%/timolol 0, 5% (TTF C) fixed combination from previous monotherapies. Methods: Prospective, open-label, observational, multicenter cohort. A change was done from prior monotherapy at day 0 to TTF C dosed once a day, regardless in the evening or in the morning, without washout period. Active evaluation of systemic and local tolerability (adverse events), and efficacy ie. intraocular pressure (IOP) lowering was done at control 1 (day 30), control 2 (day 90) and control 3 (day 120). Results: 40/155/170 patients (79/309/339 eyes) completed the study (120 days/ 90 days/baseline, respectfully). At control 1 excluded were patients with low tolerability (severe hyperemia (6 patients), discomfort (4), chest pain (1)) and non responders (IOP lowering less than 15% from baseline IOP or target IOP >18 mmHg (4 patients)). Mean IOP at control 1 was 15, 92±1, 85 mm Hg (21, 66% reduction) for 155 patients (non responders excluded), at control 2 was for 155 patients 15, 67±2, 17 mm Hg (21, 14% reduction), and at control 3 for 40 patients 16, 28±1, 59 mm Hg (19, 86% reduction). At control 2 analysis of IOP reduction by 4 groups of previous monotherapy (timolol 0, 5% (N=33/66), latanoprost 0, 005% (N=49/98), betaxolol 0, 5% (N=30/60), and travoprost 0, 004% (N=43/85) was performed. 40 patients/79 eyes endured to control 3 (after day 90 free samples were not available for all patients). Analysis of IOP reduction by 4 groups of previous monotherapy medications was performed (timolol 0, 5%(N=7/14), latanoprost 0, 005% (N=14/28), betaxolol 0, 5% (N=7/14), travoprost 0, 004% (N=12/23)). Conclusions: Changing patients from prior monotherapy to TTF C can provide on average a further reduction in IOP, while demonstrating a favorable safety profile.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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