Naslov
Inflammation and endothelial dysfunction in pathogenesis of diabetic retinopathy in patients with type 2 diabetes

Autori
Tomić, Martina ; Novak, Branko ; Ljubić, Spomenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Diabetes - a Threat to Mankind ; 2013., B23 / - , 2013

Skup
Symposium on diabetes and its complications: Diabetes - a threat to mankind

Mjesto i datum
Helsinki, Finska, 07.06.2013. - 08.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
diabetic retinopathy; inflammation; endothelial dysfunction

Sažetak
The pathogenesis of diabetic retinopathy (DR) is insufficiently understood and presumed to possibly involve inflammation and endothelial dysfunction. The aim of the study was to investigate the relationship between inflammation markers, other markers of endothelial dysfunction and anthropometric parameters and their association with DR in patients with type 2 diabetes, divided into three groups: no retinopathy (n=65), mild/moderate nonproliferative (NPDR ; n=19) and severe NPDR/proliferative retinopathy (PDR ; n=23). The groups did not differ in the levels of inflammation markers, other markers of endothelial dysfunction and anthropometric parameters. C-reactive protein was correlated with fibrinogen, HbA1c, LDL-cholesterol, BMI, WC, WHR and C index. HbA1c was correlated with cholesterol, LDL-cholesterol, BMI and WC. Logistic regression analysis showed that diabetes duration and HbA1cmedian were the main predictors of retinopathy. The study demonstrated that the association between obesity, inflammation and other risk factors plays an important role in endothelial impairment involved in the pathogenesis of DR.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA