Naslov
QSAR Study of 1,8-Naphthyridin-4-ones as Inhibitors of Photosystem II

Autori
Šoškić, Milan ; Plavšić, Dejan

Izvornik
Journal of Chemical Information and Computer Sciences (0095-2338) 41 (2001), 5; 1316-1321

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
QSAR; 1;8-naphthyridin-4-ones; inhibition; photosystem II

Sažetak
The effect of substituents on in vitro activity of 20 1,8-naphthyridin-4-ones, a novel class of photosystem II inhibitors, was studied. A four parameter QSAR model based on the molecular connectivity indices was developed which accounts for about 87% of the variations in inhibitory potencies of these compounds. The model suggests that the position, size and polarity of substituents are factors that predominantly control their activity. By using physicochemical constants, a quantitative model for both 1,8-naphthyridin-4-ones and structurally related 2-trifluoromethyl-4-hydroxyquinoline derivatives was proposed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA