Pregled bibliografske jedinice broj: 712286
The importance of flavonoids-CYP enzymes interactions
The importance of flavonoids-CYP enzymes interactions // CEEPUS Summer School 2014, Book of Abstracts / Prodan Zitnik I., Marc J., Dumic J. (ur.).
Ljubljana, 2014. str. 60-61 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 712286 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The importance of flavonoids-CYP enzymes interactions
Autori
Fumić, Barbara ; Dumić, Jerka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
CEEPUS Summer School 2014, Book of Abstracts
/ Prodan Zitnik I., Marc J., Dumic J. - Ljubljana, 2014, 60-61
ISBN
978-961-6378-60-4
Skup
International CEEPUS Summer School 2014
Mjesto i datum
Portorož, Slovenija, 24.08.2014. - 29.08.2014
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Flavonoids; CYP enzymes
Sažetak
Flavonoids represent a group of phytochemicals exhibiting a wide range of biological activities arising mainly from their antioxidant properties and ability to modulate several enzymes or cell receptors. In recent years, flavonoids have attracted increasing interests due to their various beneficial pharmacological effects including anti- inflammatory, anti-allergic, antiviral, anticancer, and antioxidant properties. However, not all flavonoids and their actions are necessarily beneficial. Some flavonoids have mutagenic and/or prooxidant effects and can also interfere with essential biochemical pathways. Among the proteins that interact with flavonoids, cytochrome P450 monooxygenases (CYPs) play a prominent role. CYPs are heme-containing mixed- function oxidases, very important in metabolism of hydrophobic endogenic substrates (sterols, prostaglandins, fatty acids) and ingested foreign compounds, xenobiotics (drugs, food components). The milestone of the completion of the sequence of the human genome revealed the presence of 57 different active genes encoding CYPs. All genes encoding CYP enzymes are polymorphic. The functional importance of the variant alleles, however, differs and the frequencies of their distribution in different ethnic groups also differ. Flavonoid compounds influence CYP enzymes in several ways: flavonoids induce the expression of several CYPs and modulate (inhibit or stimulate) their metabolic activity. In addition, some CYPs participate in metabolism of flavonoids.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
