Pregled bibliografske jedinice broj: 711333
Changes in cAMP levels in the developing opossum spinal cord at the time when regeneration stops being possible.
Changes in cAMP levels in the developing opossum spinal cord at the time when regeneration stops being possible. // Cellular and molecular neurobiology, 27 (2007), 7; 883-888 doi:10.1007/s10571-007-9208-3 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 711333 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Changes in cAMP levels in the developing opossum spinal cord at the time when regeneration stops being possible.
Autori
Mladinić, Miranda
Izvornik
Cellular and molecular neurobiology (0272-4340) 27
(2007), 7;
883-888
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
Spinal cord Opossum cAMP Regeneration Development
Sažetak
Cyclic AMP (cAMP) is an important second messenger in signaling pathways that regulate cellular processes involved in development and regeneration. The changes in cAMP content of opossum spinal cords have been studied during the critical period of development, when the ability to regenerate axons after injury is lost. Endogenous cAMP levels were measured in tissue homogenates, and cAMP immunoreactivity was displayed in sections of lesioned and non- lesioned opossum P6 (can regenerate) and P13 (cannot regenerate) spinal cords. There was a significant decrease of the cAMP levels during the period critical for regeneration, while the level of cAMP was increased in P6 spinal cords after injury. Moreover, 5 mM db-cAMP induced growth in vitro of the injured axons in the spinal cord that has lost the capacity to regenerate.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju
Profili:
Miranda Mladinić Pejatović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE