Naslov
Immune functions in children with malignant embryonal tumors

Autori
Sabioncello, Ante ; Rabatić, Sabina ; Svoboda Ivana, Mažuran, Renata ; Crnojević-Ivanušić Ružana ; Jovančević, Milivoj ; Batinica, Stipe ; Dekaris, Dragan

Izvornik
Periodicum biologorum (0031-5362) 92 (1990), 1; 151-152

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
tumours; embrional; malignant; immune status; children

Sažetak
The aim was to investigate some of the parameters of systemic cellular immune reactions in children suffering with malignant embrional tumors. The blood was collected before surgery or after cytostatic and/or radiotherapy at the time when the leucocyte count reached at least 3x10^9/L. The lower percentages of T, Th and B lymphocytes and no reactivity to PPD in the migration inhibition test were found. The NK activity and phagocytic functions were impaired. Patients without metastases had lower ADCC than both control and patients with metastases. Proliferative capacity of lymphocytes was increased and more pronounced in patients with metastases. Analysis of prognostic meanings of our findings needs additional testing.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA