Pregled bibliografske jedinice broj: 711115
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor // Journal of neural transmission, 121 (2014), 6; 665-669 doi:10.1007/s00702-013-1150-6 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 711115 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor
Autori
Drinovac, Višnja ; Bach-Rojecky, Lidija ; Lacković, Zdravko
Izvornik
Journal of neural transmission (0300-9564) 121
(2014), 6;
665-669
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Botulinum toxin type A; Neuropathic pain; Formalin-induced pain; GABA; c-Fos
Sažetak
The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
108-1080003-0001 - NEUROTRANSMITORI I NOVI MEHANIZMI DJELOVANJA LIJEKOVA I OTROVA (Lackovic, Zdravko, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
