Naslov
Sex steroid receptors in intracranial tumors

Autori
Romić-Stojković, Ranka ; Jovančević, Milivoj ; Jadro- Šantel, Dubravka ; Grčević, Nenad ; Gamulin, Stjepan

Izvornik
Cancer (0008-543X) 65 (1990), 9; 1968-1970

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
human ; malignant tumor ; benign neoplasm ; nervous system diseases ; sex steroid hormone ; pathophysiology ; androgen ; progesterone ; estrogen ; hormonal receptor ; tumor

Sažetak
Estrogen (ER), progestin (PGR), and androgen (AR) receptors were assayed in cytosols prepared from 38 various intracranial tumors. The receptors were in the following proportions (number of receptor- positive/number of tumors examined): meningiomas were positive for PGR (4/6) and AR (2/5) ; glioblastomas were also positive for PGR (3/21) and AR (7/21) ; astrocytomas were positive only for PGR (4/5) ; and oligodendrogliomas only for AR. In two hamartomas AR was present, while in one chordoma both PGR and AR were present. In this latter tumor ER were not assayed due to insufficient material. The receptors were present in concentrations between 10 and 20 fmol/mg protein. Exceptions were two meningiomas and a chordoma with a high concentration of PGR and AR. Our results support the notion that a proportion of intracranial tumors contains sex steroid receptors, and some of these tumors might be hormonally dependent.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA