Naslov
Utjecaj C(3)-supstituenta na kemijske transformacije 1, 4-benzodiazepin-2-ona pri koordinaciji Cu(II)
(The influence of the C(3)-substituent on chemical transformations of 1, 4-benzodiazepin-2-ones upon Cu(II)-coordination)

Autori
Višnjevac, Aleksandar ; Tušek-Božić, Ljerka ; Majerić-Elenkov, Maja ; Šepac, Dragan ; Šunjić, Vitomir ; Kojić-Prodić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Sažeci s XVII hrvatskog skupa kemičara i kemijskih inženjera / Visković, Ivan - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI) ; Hrvatsko kemijsko drustvo, 2001

Skup
XVII hrvatsko skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 10.06.2001. - 13.06.2001

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Sažetak
1, 4-Benzodiazepin-2-one derivatives are well known CNS active compounds. Well documented properties of nitrogen ligands to form metal complexes possessing biological activity even higher than the free ligands, prompted us to prepare novel copper complexes of 3-hydroxymethyl- (1), 3-acetoxymethyl- (2) and 3-methyl- (3) derivatives of 7-bromo-1, 3-dihydro-1-methyl-2H-1, 4-benzodiazepin-2-one. The synthesis, some spectroscopic properties and X-ray structure analysis of free ligands as well as the copper(II)dichloride complexes are presented. During the crystal growth of complexes, however, unexpected chemical transformations occurred. Mechanisms of these chemical transformations are proposed. The complexes were prepared by reaction of copper(II)chloride dihydrate and benzodiazepine ligands in 1:1 metal to ligand ratios in different solvents: ligand 1 in absolute ethanol whereas ligands 2 and 3 in a 1:1 mixture of dichloromethane and ethanol. In the first case (ligand 1) two kinds of crystalline complexes were obtained by slow evaporation of ethanol at the room temperature: complex B (green) and complex C (black) which are, as shown by the X-ray structure analysis, products of oxygenation (B) and subsequent oxydative ring contraction (C) of 1. In the case of 2, upon copper coordination a green [CuCl2(2)] was afforded (complex D). Only after heating, dark brown crystals are formed, which are shown to be a quinazoline derivative copper complex (E), a product of the oxydative ring contraction similar as encountered by complexation of 1. However, chemical transformation of the ligand was not detected for complexation of copper to 3, only a green [CuCl2(3)] complex (F) was formed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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