Naslov
Efficacy and tolerability of paliperidone palmitate long-acting injectable antipsychotic in first-episode schizophrenic patients

Autori
Petrić, Daniela ; Rački, Valentino ; Graovac, Mirjana ; Kaštelan, Ana ; Grahovac, Tanja ; Vučić Peitl, Marija ; Frančišković, Tanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book: 29 th World Congress of Neuropsychopharmacology / CINP - Vancouver : CINP, 2014, 75-75

Skup
29 th World Congress of Neuropsychopharmacology

Mjesto i datum
Vancouver, Kanada, 22.06.2014. - 26.06.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
paliperidone ; schizophrenia ; long acting drugs ; first episode
(pasliperidone ; schizophrenia ; long acting drugs ; first episode)

Sažetak
Objective: Aim of the paper is to assess the therapeutic efficacy and tolerability of paliperidone palmitate long-acting injectable antipsychotic in first-episode schizophrenic patients. The management of patients with a first-episode of psychosis remains a challenge. Treating patients with paliperidone palmitate avoids the issue of non-compliance. Methods: The research included 17 patients aged 16 to 22 years who were diagnosed in accordance with the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. All patients were assessed six times over six months using the following clinical scales: Positive and Negative Syndrome Scale, Clinical Global Impression - Severity and Improvement Scale, Personal and Social Performance Scale. Primary safety measures included incidence of adverse events. Results: In this six months analysis 88.2% of patients with first-episode psychosis achieved remission, which was significantly associated with early treatment response. Patients achieving remission demonstrated a trend towards greater improvement in function, health status and productivity. Conclusion: All doses of once-monthly paliperidone palmitate were efficacious and generally tolerated. Earlier application of paliperidone palmitate results in lower relapse rates, better reaction to therapy, achieving remission and full recovery.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA