Naslov
Pregnancy outcome of mothers with diabetic nephropathy

Autori
Herman, Mislav ; Đelmiš, Josip ; Ivanišević, Marina ; Blajić, Jozo ; Starčević, Vito ; Sokol, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXXV. Alpe Adria Meeting of Perinatal Medicine XXVII Alpe Adria Perinatal Congress / Kornhauser, Cerar Ljilijana ; Lučovnik, Miha - Bled : Kubelj d.o.o, 2013, 72-72

ISBN
978-961-6484-12-1

Skup
XXXV. Alpe Adria Meeting of Perinatal Medicine XXVII Alpe Adria Perinatal Congress

Mjesto i datum
Bled, Slovenija, 20.09.2013. - 21.09.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Type-1 diabetic; nephropaty; perinatal outcome; hypertension/preeclampsia

Sažetak
Diabetic nephropathy increases risk developing hypertension/ preeclampsia in diabetic mothers and increase perinatal morbidity and mortality rate. The aim of the study was to investigate: 1) incidence of diabetic nephropathy in pregnant women with type-1 diabetes mellitus, 2) frequency of hypertension/preeclampsia in mothers with diabetic nephropathy, 3) perinatal outcome in mothers with diabetic nephropathy. Patients and methods. During the period 2004 to 2011 retrospective analyses of 396 pregnant women with type-1 DM was performed. All patients were divided in five groups: I. pregnancies with type-1 DM without complications (309 ; 78%), II. pregnancies with type-1 DM and non proliferative retinopathy (n=29 ; 7.3%), III. pregnancies with type-1 DM and proliferative retinopathy (n=23 ; 5, 8%), IV. pregnancies with type-1 DM and peripheral neuropathy (n=5 ; 1, 3%), and V. pregnancies with type-1 DM and diabetic nephropathy (n=30 ; 7, 6%). Results. Incidence of diabetic nephropathy was 7.6%. Hypertension/ preeclampsia was developed in 14 (47%) of all pregnant type-1 DM patients with diabetic nephropathy, and only in 12% of type-1 DM patients without any complications of diabetes. When the groups were compared for age, height, body weight, gained weight during pregnancy, body mass index, HbA1c values and acid base status of umbilical vein after statistical analyses was found no significant difference. The significant statistical difference was found among diabetic mothers without complications of diabetes and those with diabetic nephropathy when compared to gestational age at delivery, new borns weight and ponderal index. In the group of mothers with diabetic nephropathy preterm delivery rate was significantly higher than in mothers without complications of type-1 DM (p=9.035). Among the mothers with type-1 DM without complications perinatal mortality was 2.8%, and in type-1 DM mothers with diabetic nephropathy perinatal mortality was 0%. Conclusion. Diabetic nephropathy is a serious complication of DM and pregnancies of mothers with such complications have to be closely monitored in order to achieve such good perinatal outcome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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