Naslov
RhBMP-7 treated IRBR implants on rat calvarial defects

Autori
Zoričić Cvek, Sanja ; Đudarić, Luka ; Cvijanović, Olga ; Marić, Ivana ; Šestan, Branko ; Šantić, Veljko ; Pilipović, Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6th International Symposium of Clinical and Applied Anatomy - Book of Abstracts / Zoričić Cvek, Sanja - Rijeka, 2014, 50-50

Skup
6th International Symposium of Clinical and Applied Anatomy

Mjesto i datum
Krk, Hrvatska; Rijeka, Hrvatska, 26.06.2014. - 29.06.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
rhBMP-7; IRBR implants; bone

Sažetak
Aim: The cellular and molecular sequences of the osteogenesis induced by rhBMP-7 bound to inactive rat bone residue (IRBR) as a carrier implanted in rats have been studied at calvarial defect. Methods and experimental design: To create a parcial defect of calvarial rat bone, periosteum and bone of the frontoparietooccipital complex were grinded with dental burr and special care was taken to avoid cranial wall opening. The implants were harvested at day 7th, 12th and 21th. Tissue samples were analysed by histology, histochemistry and histomorphometry. Results: The results of this study showed different initial tissue response in relation to control samples of implants (contain no active osteoinductive BMP-7). On rat calvarial deffect BMP-7 induced direct bone formation (intramembranous bone formation) and fuses with the underlying bone deffect. In the underlying bone remodeling is active as early as day 12th and is completely fused with the impalnt by day 21st.The results of histomorphometry showed more prounanced and rapid osteogenesis in relation to control animals. Conclusion: The results of this study suggest that rhBMP-7 induced early bone formation and promote osteogenesis to deffect healing. The bone forming process is manly direct ie. intramembranous bone formation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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