Naslov
Syntheses and characterization of liposome-incorporated adamantyl aminoguanidines

Autori
Šekutor, Marina ; Štimac, Adela ; Mlinarić-Majerski, Kata ; Frkanec, Ruža

Izvornik
Organic & biomolecular chemistry (1477-0520) 12 (2014), 31; 6005-6013

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adamantane; guanidinium; liposomes; molecular recognition; drug delivery

Sažetak
A series of mono and bis-aminoguanidinium adamantane derivatives has been synthesized and incorporated into liposomes. They combine two biomedically significant molecules, the adamantane moiety and the guanidinium group. The adamantane moiety possesses the membrane compatible features while the cationic guanidinium subunit was recognized as a favourable structural feature for binding to complementary molecules comprising phosphate groups. The liposome formulations of adamantyl aminoguanidines were characterized and it was shown that the entrapment efficiency of the examined compounds is significant. In addition, it was demonstrated that liposomes with incorporated adamantyl aminoguanidines effectively recognized the complementary liposomes via the phosphate group. These results indicate that adamantane derivatives bearing guanidinium groups might be versatile tools for biomedical application, from studies of molecular recognition processes to usage in drug formulation and cell targeting.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA