Naslov
Neurophysiologic markers of motor speech related cortical areas.

Autori
Deletis, Vedran ; Rogić, Maja ; Fernandez Conejero I

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Clinica Croatica. 6 th Congress of the Croatian Neurosurgical Society and the Joint Meeting with the Slovenian Neurosurgical Society / - Zagreb : Klinički bolnički centar Sestre milosrdnice ; Institut za medicinska istraživanja i medicinu rada, 2011, 67-67

Skup
6 th Congress of the Croatian Neurosurgical Society and the Joint Meeting with the Slovenian Neurosurgical Society

Mjesto i datum
Opatija, Hrvatska, 25.05.2011. - 28.05.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Neurophysiologic markers speech areas; TES; DCS; TMS

Sažetak
Aim of the study: To detect specific neurophysiologic markers in the laryngeal muscles, after electric and magnetic stimulation of prefrontal cortices, corresponding to the specific cortical areas related to the motor production of speech. Methods: Transcranial electric stimulation (TES), direct electrical stimulation (DCS) and navigated transcranial magnetic stimulation (nTMS), of the frontal cortex has been employed with registration of the specific EMG responses (markers) in the laryngeal muscles ; short latency response (SLR) and long latency response (LLR). Results: In 10 healthy subjects and 10 patients all three methods of stimulation elicited specific responses in the laryngeal muscles: when the primary motor cortical area (M1) was stimulated, SLR was obtained and when phonological part of Broca area was stimulated, LLR was obtained. In the patient’s group, during awake craniotomy DCS with an either 50 Hz stimulation (Penfield technique), or short train of 5 pulses of 250 Hz, resulted in speech arrest. This identical cortical point generates LLR. Conclusion: We conclude that neurophysiologic markers recorded pre and intraoperatively correspond to the M1 for laryngeal muscle (SLR) and phonological part of the Broca region (LLR), with strong evidence coming from data obtained by nTMS and DCS. With new technology of nTMS not only SLR and LLR from laryngeal muscles will be available preoperatively, but a reliable method for preoperative eliciting speech arrest, facilitating preoperative mapping of motor speech related cortical areas, and help planning surgery of the pathology in the vicinity of those areas.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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