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Pregled bibliografske jedinice broj: 700162

Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives

Gazivoda Kraljević, Tatjana; Ilić, Nataša; Stepanić, Višnja; Sappe, Lana; Petranović, Jasna; Kraljević Pavelić, Sandra; Raić-Malić, Silvana
Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives // Bioorganic & medicinal chemistry letters, 24 (2014), 13; 2913-2917 doi:10.1016/j.bmcl.2014.04.079 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 700162 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives

Autori
Gazivoda Kraljević, Tatjana ; Ilić, Nataša ; Stepanić, Višnja ; Sappe, Lana ; Petranović, Jasna ; Kraljević Pavelić, Sandra ; Raić-Malić, Silvana

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 24 (2014), 13; 2913-2917

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-Alkylated pyrimidine derivatives ; C-6-isobutyl pyrimidine ; C-6-propyl pyrimidine ; In silico analysis ; Antiproliferative evaluation

Sažetak
A series of novel N-alkylated C-6-isobutyl- or -propyl pyrimidine derivatives were synthesized and their antiproliferative effect was evaluated on a panel of tumor cell lines including leukemia cell line K562 and normal diploid human fibroblasts. N-methoxymethylated 5-methylpyrimidin-2, 4-dione with di(benzyloxy)isobutyl at C-6 (14b) showed the strongest effect on the cell growth at micromolar concentrations. Mechanisms of action for the lipophilic compound 14b predicted in silico, pointed to its anticancer and antimetastatic potential exerted through inhibition of DNA or RNA polymerases and adhesion molecules. The latter mechanism has been supported in vitro for adherent tumor cell lines.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
MZOS-098-0982464-2511 - Epigenetičke i imunomodulatorne promjene u zloćudnim tumorima glave i vrata (Gall-Trošelj, Koraljka, MZOS ) ( CroRIS)
MZOS-125-0982464-2925 - Razvoj i primjena novih molekula u pozitron-emisijskoj tomografiji (PET) (Raić-Malić, Silvana, MZOS ) ( CroRIS)
MZOS-335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Silvana Raić-Malić (autor)

Avatar Url Višnja Stepanić (autor)

Avatar Url Tatjana Gazivoda Kraljević (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Gazivoda Kraljević, Tatjana; Ilić, Nataša; Stepanić, Višnja; Sappe, Lana; Petranović, Jasna; Kraljević Pavelić, Sandra; Raić-Malić, Silvana
Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives // Bioorganic & medicinal chemistry letters, 24 (2014), 13; 2913-2917 doi:10.1016/j.bmcl.2014.04.079 (međunarodna recenzija, članak, znanstveni)
Gazivoda Kraljević, T., Ilić, N., Stepanić, V., Sappe, L., Petranović, J., Kraljević Pavelić, S. & Raić-Malić, S. (2014) Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives. Bioorganic & medicinal chemistry letters, 24 (13), 2913-2917 doi:10.1016/j.bmcl.2014.04.079.
@article{article, author = {Gazivoda Kraljevi\'{c}, Tatjana and Ili\'{c}, Nata\v{s}a and Stepani\'{c}, Vi\v{s}nja and Sappe, Lana and Petranovi\'{c}, Jasna and Kraljevi\'{c} Paveli\'{c}, Sandra and Rai\'{c}-Mali\'{c}, Silvana}, year = {2014}, pages = {2913-2917}, DOI = {10.1016/j.bmcl.2014.04.079}, keywords = {N-Alkylated pyrimidine derivatives, C-6-isobutyl pyrimidine, C-6-propyl pyrimidine, In silico analysis, Antiproliferative evaluation}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2014.04.079}, volume = {24}, number = {13}, issn = {0960-894X}, title = {Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives}, keyword = {N-Alkylated pyrimidine derivatives, C-6-isobutyl pyrimidine, C-6-propyl pyrimidine, In silico analysis, Antiproliferative evaluation} }
@article{article, author = {Gazivoda Kraljevi\'{c}, Tatjana and Ili\'{c}, Nata\v{s}a and Stepani\'{c}, Vi\v{s}nja and Sappe, Lana and Petranovi\'{c}, Jasna and Kraljevi\'{c} Paveli\'{c}, Sandra and Rai\'{c}-Mali\'{c}, Silvana}, year = {2014}, pages = {2913-2917}, DOI = {10.1016/j.bmcl.2014.04.079}, keywords = {N-Alkylated pyrimidine derivatives, C-6-isobutyl pyrimidine, C-6-propyl pyrimidine, In silico analysis, Antiproliferative evaluation}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2014.04.079}, volume = {24}, number = {13}, issn = {0960-894X}, title = {Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives}, keyword = {N-Alkylated pyrimidine derivatives, C-6-isobutyl pyrimidine, C-6-propyl pyrimidine, In silico analysis, Antiproliferative evaluation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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