Naslov
Serum level of endothelial lipase, lipid profile and inflammatory markers in acute heart failure patients with overlapping metabolic syndrome ; Clinical Medical Sciences - Research Proposal

Autori
Potočnjak, Ines ; Degoricija, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
PhD Programme Biomedicine and Health Sciences PhD Day 2014 Abstract Book / Jakopović, Marko ; Lacković, Zdravko - Zagreb : Kerschoffset, 2014, 141-141

ISBN
978-953-6255-60-3

Skup
University of Zagreb School of Medicine PhD Day 2014

Mjesto i datum
Zagreb, Hrvatska, 23.05.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
heart failure ; metabolic syndrome ; lipase ; lipids ; markers

Sažetak
Introduction: Heart failure (HF) is defined as an abnormality of cardiac structure or function lesion leading to failure of the heart to deliver oxygen at a rate commensurate with the requirements of the metabolizing tissues, despite normal filling pressures. Metabolic syndrome (MS) is a tendency of concomitant risk factors to group: central obesity, elevated serum triglycerides, lowered HDL-cholesterol, glucose intolerance and hypertension. Since MS is present in many patients with acute HF (AHF), this overlapping is important for further investigation. Hypothesis: Elevated serum level of endothelial lipase, inflammatory markers and lipid profile in AHF patients with overlapping MS produce worse outcome. Aims: To investigate weather elevated serum level of endothelial lipase, inflammatory markers and lipid profile can predict worse outcome in patients with AHF and overlapping MS. Matheraials and methods: The stdy will be observational, prospective and performed on AHF patients recruited from the Sisters of Charity University Hospital Centre, Zagre, Croatia, in a roughly estimated period of 12 months. Patients will be divided in the two groups depending on the presence of MS. The groups will be compared by analysing lipid profile and inflammatory biomarkers considering the following parameters: total lipids, cholesterol, HDL, LDL, tryglicerides, VLDL, endothelial lipase (EL), lipoprotein A, hs-CRP, TNF alfa, IL-6, IL-8, paraoxonase activity in HDL, and its total anti- inflammatory activity. Patients will be treated according to standard treatment protocol. The study will be performed according to Good Clinical Practise and Helsinki Declaration's principles, and approved by the local Ethics Committee. Input parameters will include the patients' data: medical history, current clinical status, laboratory and diagnostic procedures. Additionally 3x6 mL of full blood samples will be collected, two at admission, and one on the third day of hospitalzation, immediately centrifuged, with serum divided into plastic tubes, and frozen at -30 C. Once sample collection is completed, serum biochemical analysis will be performed at Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University Graz, Austria. Output parameters will include outcome measures: treatment duration, performed procedures, mortality and NYHA classification. Expected scientific contribution: The results should determine that investigated increased laboratory markers can be predictors of morbidity and mortality of AHF patients with overlaping MS. Poster code: B-9-53.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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