Naslov
Inherited coagulation disorders in children with arterial ischemic stroke and transient ischemic attack

Autori
Coen Herak, Desiree

Izvornik
Clinical biochemistry (0009-9120) 44 (2011), 7; 512-513

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni

Ključne riječi
children ; arterial ischemic stroke ; transient ischemic attack ; coagulation

Sažetak
Stroke in children, including ischemic and hemorrhagic, is a heterogeneous disorder, increasingly recognized as an important cause of childhood disability and lifelong morbidity. There is increasing evidence that besides a wide range of already identified risk factors, several genetic polymorphisms may be implicated in the etiology of pediatric AIS.A genotype analysis for FVL, PT, MTHFR and four common GP polymorphisms (GP IIIa: HPA-1 ; GP Ibα: HPA-2 ; GP IIb: HPA-3 ; GP Ia: HPA-5) was performed in 73 children (47 boys and 26 girls) aged < 18 years with AIS confirmed by neuroimaging, and in 36 children (13 boys and 23 girls) with TIA, in order to establish the possible relationship between the investigated polymorphisms and selected disorders. The control group consisted of 112 children (78 boys and 34 girls) aged ≤ 18 years from the same geographical region with no history of neurologic or thromboembolic diseases. The present study shows that among investigated polymorphisms, only FVL was significantly associated with an increased risk for pediatric AIS, particularly in children with PAIS. Furthermore, in this study a mild protective effect of the HPA-3b allele was found in children with AIS and CAIS. In contrast to pediatric stroke, inherited prothrombotic risk factors have not been investigated in children with TIA as a separate group. The results obtained in the present study demonstrated a strong association between FVL and TIA, similar to that obtained for AIS, suggesting a possible link between stroke and TIA in children. Furthermore, significantly higher frequencies of HPA-2b and -5b alleles, HPA-5a/b, and combined HPA-2a/b and -5a/b genotypes detected in children with TIA than in control subjects suggests that platelet GP polymorphisms implicated in platelet adhesion may additionally increase the risk of TIA, but not of pediatric AIS.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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