Naslov
Ultraviolet Radiation and the Skin Immune Response

Autori
Nola, Ivana ; Kostović, Krešimir ; Lugović, Liborija ; Meštrović Štefekov, Jelena ; Sjerobabski Masnec, Ines

Izvornik
Acta clinica Croatica (0353-9466) 42 (2003), 2; 119-124

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
UV radiation ; skin ; immune response

Sažetak
At present, ultraviolet radiation (UVR) represents one of the most important environmental factors affecting mankind. Besides the beneficial effects of UVR such as vitamin D production, it is known that UVR can lead to adverse effects on human health. The best known harmful effects are sunburns, tumors of the skin and ocular damage. It is noteworthy that UVR effects are not restricted to skin- associated infections, as there is strong evidence for their association with systemic (non-skin- associated) infections as well. Alterations in immune functions that are induced by UVR are initiated by the absorption off light energy by chromophores and their transformation into photoproducts. Some of them are removed by repair mechanisms ; others induce signal transduction pathways, whereas some exhibit cytotoxicity. The observable skin response may occur within minutes of light exposure (e.g. urticaria) or may take days (e.g. inhibition of contact hypersensitivity), or much longer periods to be expressed (e.g. tumors). Today, artificial UVR (phototherapy) is used in dermatology for induction of immunomodulation in many forms of autoimmune and/or hyperimmune responses in the skin.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA