Naslov
Nonaromatic naphthalan for the treatment of oral mucosal diseases

Autori
Andabak Rogulj, Ana ; Alajbeg, Ivan ; Džanić, Emir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2014 ; 117 (5) / - , 2014, E382-e382

Skup
Frontiers in Oral medicine, 2014

Mjesto i datum
Orlando (FL), Sjedinjene Američke Države, 09.04.2014. - 12.04.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nonaromatic naphthalan ; treatment ; oral mucosal diseases

Sažetak
Objectives: Nonaromatic naphthalan (NAVS) is a purified natural oil derivative, abundant in steranes (geogenic „steroids“). The purpose of this study is to evaluate the effectiveness of NAVS in the treatment of oral mucosal diseases (oral lichen planus (OLP), recurrent aphthous ulcerations (RAU) and cicatricial pemphigoid (CP)). Methods: We applied NAVS oil in adhesive paste in patients with clinically and histologically proven OLP, in patients with RAU (double blind randomized ; topical betamethasone in adhesive paste used as control), and in 1 subject with CP (open label), three times daily during 4 weeks. The severity of the OLP lesions was objectively scored. The number and diameter of RAU lesions were also assessed on days 3 and 5. The intensity of pain and discomfort was determined using visual analog scale (VAS) and „Oral health impact profile“(OHIP-14) before and after therapy. Statistical analysis was performed by use of Wilcoxon test for paired samples to evaluate the effect of treatment in each group. Treatment effect between the groups was performed by Mann-Whitney test ; p values lower than 0.05 were considered significant. Results: The results of this study showed that NAVS has successfully reduced the clinical signs and symptoms of OLP ; has reduced the number, diameter and symptoms in patients with RAU statistically comparable with corticosteroids. NAVS has reduced clinical signs in 1 CP patient. Conclusion: These results indicate the good performance of NAVS as a potential alternative to corticosteroids in treatment of oral mucosal diseases.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

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