Naslov
A rapid profiling of hypolipidemic agents in dietary supplements by direct injection tandem mass spectrometry

Autori
Sertić, Miranda ; Mornar, Ana ; Nigović, Biljana

Izvornik
Journal of food composition and analysis (0889-1575) 34 (2014), 1; 68-74

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
natural cholesterol-lowering products ; dietary supplements safety ; regulatory challenge ; supplement composition ; direct injection mass spectrometry ; fingerprint analysis ; fragment analysis ; hyperlipidemia ; food composition ; food analysis ; food safety

Sažetak
A new, fast-screening method for identification of various pharmacologically active ingredients in cholesterol-lowering dietary supplements using direct injection mass spectrometry was developed. The optimized method was proven to be useful for multitarget screening: 17 compounds of interest were identified, including monacolin K and its acid form, cynarin, green tea catechines, genistein, daidzein, guggulsterones, allicin and l- arginine. The method was successfully applied for the fingerprint analysis of dietary supplements containing only one or several cholesterol-lowering agents including lovastatin registered as a drug. According to the obtained results, it is apparent that cholesterol-lowering dietary supplements are poorly standardized, as two samples did not contain active ingredients (monacolin K, monacolin K acid form and cynarin). Moreover, the application of the proposed direct injection method to quality control of cholesterol-lowering dietary supplements may be proposed for the routine analysis of a large number of samples in the laboratories of regulatory agencies.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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