Naslov
Synthesis of Nucleobase-Cyclam Conjugates and Transition Metal Complexes

Autori
Matić, Josipa ; Saftić, Dijana ; Ban, Željka ; Žinić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Macrocycles: synthesis, medicinal chemistry and biological activity / - Zagreb, 2014, 1-1

Skup
Macrocycles: synthesis, medicinal chemistry and biological activity

Mjesto i datum
Zagreb, Hrvatska, 28.04.2014. - 29.04.2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Nucleobase-Cyclam Conjugates ; Transition Metal Complexes ; Nucleobase Derivatives

Sažetak
The development of metal complexes as new chemotherapeutics or diagnostic agents has rapidly increased in recent times. Complexes containing biologically important copper ions are promising agents in the cure of tumor diseases while copper is important for many processes in high proliferative cells such are tumor cells. The N-1-sulfonylcytosine 1, its molecular complex Cu(1-TsC-N3)2Cl2 2, and CuCl2 x 2H2O salt were tested in vitro against normal cells (WI38), human carcinoma (HeLa, CaCo2, MiaPaCa2, SW620), lymphoma (Raji) and leukemia (K562) cell lines by MTT assay. Antiproliferative capacity of the tested compounds varies (IC50 after 72 h of exposure: 4.0x10-6 M to 20x10-6 M). Leukemia and lymphoma cells were found the most sensitive to complex 2. It demonstrated higher in vitro activity against K562 cells than ligand 1 more than 100 times. C-5 substituted nucleobase derivatives are attached to cyclam in order to prepare mono and binuclear complexes (eg. Cu(II)/Zn(II)) and test their biological activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA