Naslov
Ultrastructural analysis of the protective effects of BPC 157 ethanol induced gastric lesions in rats

Autori
El Taguri Adel, Ibrahim

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, magistarski rad

Fakultet
Medicinski fakultet

Mjesto
Zagreb

Datum
Podatak o recenziji nije dostupan

Godina
1994

Stranica
93

Mentor
Seiwerth, Sven

Ključne riječi
pentadecapeptide BPC 157; peptic ulcer; gastroprotection; prostaglandins;

Sažetak
Peptic ulcer diseases are a significant cause for morbidity in humans. The current applied treatment is dominated still by approaches which are still far from the accumulating basic knowledge about the cause of this disease: and about the ever increaseingly appreciated physiological mechanisms that occur in the stomach. These mechanism help in the natural defense of the stomach against various noxious stimuli which the gastric mucosa is exposed to during life. A promising approach to treatment is to increase the stomach resistance against acidity rather than decreasing the exposure or the secretion of the acidity: the later approach is confrontend by many regulatory physiological mechanism, and might not represent the essential phatologic process in many cases. The later approach which is generally known as gastroprotection is shown to be mediated by many natural and synthetic substances. The diversity of these substances is not unexpected ; many peptides and a like substances are discovered and being added to the list of gastric juice contents. BPC is a newly discovered natural polypeptiiide that has a huge range of organoprotective effects, notably gastroprotection. Our aim is to further study this microscopically confirmed gastroprotection by submicroscopical means. We use the same procedures which had been done to evaluate the parent organoprotective compound: the Prostaglandins. These procedures involve the use of transmission and scanning electron microscopy changes through different time periods after stomach exposure to 96% ethanol. Our results showed that the BPC gastroprotective activity is a real process which could be validated morphologically at the submicroscopical level.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA