Naslov
Super-refractory status epilepticus - diagnostic and therapeutic challenges

Autori
Šulentić, Vlatko ; Hajnšek, Sanja ; Nanković, Sibila ; Petelin Gadže, Željka ; Kovačević, Ivana ; Bujan Kovač, Andreja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Neurologia Croatica / Lušić, Ivo ; Bilić, Ivica ; Džamonja, Gordan - Zagreb : Denona, 2013, 46-46

Skup
VI. hrvatski neurološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Split, Hrvatska, 06.11.2013. - 10.11.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
status epilepticus; diagnosis; drug resistance

Sažetak
Status epilepticus (SE) or prolonged seizures represent a very serious condition and neurological emergency. According to the International Classification of Epileptic seizures (ILAE classification), status epilepticus is defined as seizures lasting longer than 30 minutes or recurring seizures that last longer than 30 minutes, between which the patient does not regain consciousness. According to different studies, mortality in status epilepticus varies from 8-50%. In recent years, the term refractory or super-refractory epileptic status has been introduced. Super-refractory status epilepticus is defined as status epilepticus that lasts 24 hours or more aft er the start of anesthesia, including cases that occur after the discontinuation or reduction of anesthesia. Super-refractory status epilepticus accounts for about 15% of SE with very high mortality (30-50%). We report two patients with super-refractory status epilepticus. The first patient is a 19-year-old female with NMDA encephalitis who developed a super-refractory status epilepticus and the necessity for anesthesia was therefore longer than 20 days, but only the introduction of cyclophosphamide led to seizure cessation. The second patient, with seizures according to FIRES Febrile Infection Related Epilepsy Syndrome), in which case extensive diagnostic evaluation was unable to define the cause of status epilepticus, unfortunately died despite all accessible and intensive-care therapy. We have presented two patients who developed super-refractory status epilepticus. Th is condition is a serious neurological disorder of various etiology that has a high mortality rate and still no clear-cut therapeutic algorithms.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA