Naslov
Plasma homocysteine is associated with retinopathy in type 1 diabetic patients in the absence of nephropathy

Autori
Bulum, Tomislav ; Blaslov, Kristina ; Duvnjak, Lea

Izvornik
Seminars in Ophthalmology (0882-0538) 31 (2016), 3; 198-202

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
homocysteine; microvascular complications; retinopathy; type 1 diabetes

Sažetak
Previous cross-sectional studies suggested that plasma total homocysteine (tHcy) is associated with retinopathy in patients with type 1 diabetes (T1DM) only in cases of impaired renal function. The objective of this study was to examine whether there is independent relationship between tHcy and retinopathy in T1DM. Study included 163 normoalbuminuric patients with T1DM and normal renal function (eGFR >60≤125 mlmin-11.73m-2). Photodocumented retinopathy status was made according to the EURODIAB protocol. Patients with retinopathy were older (49 vs 42 years, p=0.001), had higher systolic blood pressure (130 vs 120 mmHg, p=0.001), triglycerides (0.89 vs 0.77 mmol/L, p=0.01), tHcy (9.8 vs 9.1 µmol/L, p=0.04) and lower eGFR (100 vs 106 mlmin-11.73m-2, p=0.03). In multivariate logistic regression analysis, only tHcy was significantly associated with risk of retinopathy in our subjects (p=0.02), with odds ratios of 1.02 to 1.43. These data suggest that tHcy is independently associated with retinopathy in normoalbuminuric T1DM with normal eGFR. Prospectives studies are needed to confirm whether higher tHcy in normoalbuminuric T1DM patients has predictive value for development of retinopathy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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