Naslov
Treatment of tension-type headache with botulinum toxin: 1-year follow-up

Autori
Relja, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Cephalagia / PJ Goadsby - Oxford : Blackwell Publishing, 2000, 336-336

Skup
Headache World 2000

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 03.09.2000. - 07.09.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Tension-type headache; therapy; botulinum toxin

Sažetak
Introduction It has been shown in double-blind, placebo controlled studies, that BTX-A is significantly better than placebo for symptomatic relief of patients eith TTH. Here we present long-term follow-up of patients treated with BTX-A for TTH. Objective To evaluete the long-term benefit of botulinum toxin type-A (BTX-A)for the symptomatic relief of pain associated with chronic tensio-type headache (TTH). Methods Twenty-five patients with TTH, who had been resistant to standard therapy, were enrolled into a 15-month, open-label, prospective study. The patients recieved BTX-A a Botox (dose range 40-90 U) by intramuscular injection into the most tender pericranial muscles every 3 months.Tenderness of the pericranial muscles was evalueted by manual palpation performed bilaterally in the frontalis, temporalis, trapezius, sternocleidomastoideus (mastoid process) muscles. Clinical assessment was performed at 4 week intervals using the total tenderness score (TTS) and a home diary kept by each patients. Result In total, 24 patients compeleted the study. There was a constant improvment in the number of headache-free days ove the 15-month period (P<0.001). TTS showed a sustained trend of decreasing during the study. In addition, headache severity was significantly lower (P<0.001) at month 9,12 and 15 compared with month 3 and 6, suggesting an improvement in qualitiy of life. Safety recors showed no serious adverse event. Conclusions: This is the first prospective long-term study where BTX-A injections ere found to be an effective and safe prophylactic treatment for TTH in patients for whom standard therapy has failed.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA