Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 691725

Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers

Moisan, Francois; Francisco, Edgar B.; Brozović, Anamaria; Duran, George E.; Wang, Yan C.; Chaturvedi, Shalini; Seetharamb, Shobh; Snyder, Linda A.; Doshi, Parul; Sikić, Branimir I.
Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers // Molecular Oncology, 8 (2014), 7; 1231-1239 doi:10.1016/j.molonc.2014.03.016 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 691725 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers

Autori
Moisan, Francois ; Francisco, Edgar B. ; Brozović, Anamaria ; Duran, George E. ; Wang, Yan C. ; Chaturvedi, Shalini ; Seetharamb, Shobh ; Snyder, Linda A. ; Doshi, Parul ; Sikić, Branimir I.

Izvornik
Molecular Oncology (1574-7891) 8 (2014), 7; 1231-1239

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
CCL2 ; CCR2 ; EMT ; paclitaxel ; carboplatin ; resistance

Sažetak
Ovarian cancer is strongly associated with a pro- inflammatory leukocyte infiltrate, and high levels of chemokines such as CCL2. CNTO 888, a neutralizing anti-human CCL2 antibody, can inhibit the pro-tumor inflammatory infiltrate and tumor growth. In the present study, we tested the hypothesis that CCL2 neutralization can inhibit tumor growth of ovarian cancer cell line pairs formed by a parental cell line and a non-multi- drug resistant (MDR) paclitaxel-resistant line. Furthermore, we investigated whether mouse stromal CCL2 plays a role in tumor growth promotion. Elevated CCL2 expression was determined by quantitative PCR in three non-MDR paclitaxel resistant (TP) ovarian cancer cell lines ES-2/TP, MES-OV/TP and OVCAR-3/TP, and compared to their related parental cells. Increased CCL2 protein expression levels in vitro and in vivo were confirmed in the drug resistant variants. In order to determine the role of CCL2 on tumor growth upon drug treatment, we established parental and non- MDR paclitaxel resistant cell lines expressing a GFP-luciferase fusion gene. These cells were implanted intraperitoneally (i.p.) and subcutaneously (s.c.) in nude mice. Mice were treated with the anti-human CCL2 antibody (CNTO 888) and the anti-mouse MCP-1 antibody (C1142), orthologous of human CCL2, with and without chemotherapy (paclitaxel or carboplatin). Tumor growth was evaluated by both bioluminescence and caliper measurements. Our results show a significant additive effect of CCL2 blockade on the efficacy of paclitaxel and carboplatin. The mechanism of this therapeutic effect was largely due to inhibition of mouse stromal CCL2. Our findings show that inhibition of CCL2 can enhance paclitaxel and carboplatin treatments of ovarian cancer.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Anamaria Brozović (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Moisan, Francois; Francisco, Edgar B.; Brozović, Anamaria; Duran, George E.; Wang, Yan C.; Chaturvedi, Shalini; Seetharamb, Shobh; Snyder, Linda A.; Doshi, Parul; Sikić, Branimir I.
Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers // Molecular Oncology, 8 (2014), 7; 1231-1239 doi:10.1016/j.molonc.2014.03.016 (međunarodna recenzija, članak, znanstveni)
Moisan, F., Francisco, E., Brozović, A., Duran, G., Wang, Y., Chaturvedi, S., Seetharamb, S., Snyder, L., Doshi, P. & Sikić, B. (2014) Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers. Molecular Oncology, 8 (7), 1231-1239 doi:10.1016/j.molonc.2014.03.016.
@article{article, author = {Moisan, Francois and Francisco, Edgar B. and Brozovi\'{c}, Anamaria and Duran, George E. and Wang, Yan C. and Chaturvedi, Shalini and Seetharamb, Shobh and Snyder, Linda A. and Doshi, Parul and Siki\'{c}, Branimir I.}, year = {2014}, pages = {1231-1239}, DOI = {10.1016/j.molonc.2014.03.016}, keywords = {CCL2, CCR2, EMT, paclitaxel, carboplatin, resistance}, journal = {Molecular Oncology}, doi = {10.1016/j.molonc.2014.03.016}, volume = {8}, number = {7}, issn = {1574-7891}, title = {Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers}, keyword = {CCL2, CCR2, EMT, paclitaxel, carboplatin, resistance} }
@article{article, author = {Moisan, Francois and Francisco, Edgar B. and Brozovi\'{c}, Anamaria and Duran, George E. and Wang, Yan C. and Chaturvedi, Shalini and Seetharamb, Shobh and Snyder, Linda A. and Doshi, Parul and Siki\'{c}, Branimir I.}, year = {2014}, pages = {1231-1239}, DOI = {10.1016/j.molonc.2014.03.016}, keywords = {CCL2, CCR2, EMT, paclitaxel, carboplatin, resistance}, journal = {Molecular Oncology}, doi = {10.1016/j.molonc.2014.03.016}, volume = {8}, number = {7}, issn = {1574-7891}, title = {Enhancement of Paclitaxel and Carboplatin Therapies by CCL2 Blockade in Ovarian Cancers}, keyword = {CCL2, CCR2, EMT, paclitaxel, carboplatin, resistance} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.