Naslov
Low level of mozaicism in couples with recurrent molar pregnancies.

Autori
Radojočić Badovinac, Anđelka ; Buretić-Tomljanović, Alena ; Starčević, Nada ; Kapović, Miljenko ; Vlastelić, Ivica ; Randić, Ljiljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstract / Seckeres Bartho, Julia - Pečuh : ASSIR, 2000, 17-17

Skup
6th Congress of the Alps-Adria Society of Immunology of Reproduction

Mjesto i datum
Pečuh, Mađarska, 27.06.2000. - 30.06.2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Mosaicism; recurent molar pregnancies

Sažetak
Most of the complete hydatidiform moles were caused by fertilisation of an empty egg by a duplicated haploid sperm, but rare exceptions may exist. Molar degeneration is caused by paternal uniparental diploidy, it means that all chromosomes of molar tissue have paternal origin. Recurrence suggests a strong genetic predisposition. In families with extensive intermarriage and recurrent molar pregnancies, unusual MHC class I and II antigens were found, but the reason for the repeated reproductive failure or striking difference in frequency of disease in different population is not known yet. Three women suffered from recurrent hydatiform molar pregnancies and their spouses, were analyzed cytogeneticaly. Low level of mosaicism 45,X was found in female and marker chromosome in male partner. We also analyzed skin fibroblast from one male partner. The low frequency of mosaicism reported here would not be detectable by conventional chromosomal analyzes of 10 mitosis per person. The implication of mosaic karyotypes in causation of molar pregnancy will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA