Naslov
Human papillomavirus status in extragenital nonmelanoma skin cancers

Autori
Ledić Drvar, Daniela ; Lipozenčić, Jasna ; Sabol, Ivan ; Bukvić Mokos, Zrinka ; Ilić, Ivana ; Grce, Magdalena

Izvornik
Clinics in dermatology (0738-081X) 32 (2014), 2; 248-252

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Human papillomavirus; basal cell carcinoma; squamous cell carcinoma

Sažetak
About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs) ; namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common malignancies in Caucasians. In fact, there is an intense connection between sunlight exposure, fair skin, HPV, and development of NMSC. We have conducted a pilot study that included tissue samples from 26 carcinoma patients, of which there were 13 BCC and 13 SCC. HPV detection and typing was done with DNA amplification and sequencing, respectively. In total, 23.1% of SCC samples (3/13) and 7.7% of BCC samples (1/13) were positive for HPV DNA. The importance of understanding all aspects of NMSC carcinogenesis may be to reveal novel therapeutic options or preventive measures for HPV containing NMSC patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
S.I.: Update on Sexually Transmitted Infections ; Jasna Lipozenčić (ur.).

POVEZANOST RADA