Naslov
Vitamin D serum levels in allergic rhinitis and chronic rhinosinusitis with or without polyposis.

Autori
Pajić Penavić, Ivana ; Đanić, Davorin ; Damjanović, Dino ; Stojadinović, Tomislav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Proceedings of the 3rd Croatian Rhinologic Congress / - , 2014, 52-53

Skup
3rd Croatian Rhinologic Congress

Mjesto i datum
Zagreb, Hrvatska, 20.02.2014. - 22.02.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Vitamin D; allergic rhinitis

Sažetak
The nasal mucosa is highly specialized immunologic barrier that has evolved to process a constant load of foreign antigens with minimal collateral inflammation. The nasal mucosa consists of an epithelial layer of ciliated, pseudostratìfied, columnar cells. The cilia and tight junctions interconnecting the epithelial cells constitute a mechanical barrier to antigenic stimulation. Deep in the epithelium reside a variety of immune cells including lymphocytes and antigen presenting cells (APCs), specifically dendritic cells and macrophages. These are key components of the acquired immune respons. The pathogenesis of nasal polyps is still unclear but the disease is believed to be the manifestation of complex inflammatory reaction. Allergic rhinitis is a common health problem caused by an immune-mediated inflammatory reaction after allergen exposure. Vitamin D, as an immunomodulatory steroid hormone, directly affects dendritic cell, monocyte, macrophage, B cell and T cell functions.|t has been shown that vitamin D have an immunomodulatory effect with a significant impact on immune function. Specifically, vitamin D regulates the mechanisms which suppress the inflamatory response and direct the differentiation fate of immune cells. Vitamin D has been shown to play an important role in asthma, and the concepts of the of the unified airway model allows the extrapolation of vitamin D as a critical player in chronic rhinosinusitis with or without nasal polyposis and in allergic rhinitis. The purpose of thís study is to discuss the role of vitamin D in allergic rhinitis, chronic rhinosinusitis with or without nasal polyposis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA