Naslov
ANALIZA AROILHIDRAZONA IZVEDENIH IZ NIKOTINOHIDRAZIDA TANDEMNOM SPEKTROMETRIJOM MASA
(TANDEM MASS SPECTROMETRIC ANALYSIS OF AROLYHYDRAZONES DERIVED FROM NICOTINIC ACID HYDRAZIDE)

Autori
Benković, Tomislav ; Stražić, Dubravka ; Galić, Nives

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
X. Susret mladih kemijskih inženjera: KNJIGA SAŽETAKA, Book of Abstracts / Findrik Blažević, Zvjezdana ; Sudar, Martina ; Šalić, Anita, Vrsalović Presečki, Ana ; Vrsaljko, Domagoj - Zagreb : Fakultet kemijskog inženjerstva i tehnologije Sveučilišta u Zagrebu, 2014, 54-54

ISBN
978-953-6470-65-5

Skup
X. Susret mladih kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 20.02.2014. - 21.02.2014

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
aroilhidrazoni; tandemna spektrometrija masa; strukturni izomeri
(aroylhydrazones; tandem mass spectrometry; structural isomers)

Sažetak
In this work detailed structural analysis of selected aroylhydrazones (Scheme 1), derived from aromatic aldehydes and nicotinic acid hydrazide, was performed by electrospray ionization mass spectrometry (ESI MS) in both positive and negative ion mode. Structural isomers of aroylhydrazones were distinguished by tandem mass spectrometry. The MS/MS spectra and fragmentation pathways of compounds 3 and 4 (derived from 3- and 4-methoxy salicylaldehyde respectively) differ due to enolimino-ketoamino tautomeric interconversion of 3. Compounds 5 and 6 (derived from 3- and 5-chloro salicylaldehyde) were distinguished by MS/MS as a result of ortho effect. Main fragmentation pathway of the 5 was loss of HCl, whereas for 6 the main pathway was loss of HCN. The fragmentation patterns of sodium adduct ions [M+Na]+ of the hydrazones were also investigated since the presence of an alkali metal influences the product-ion spectra.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA