Naslov
Prognostic significance of chromosome findings in de-novo acute myleogenous leukaemia

Autori
Mrsić, Sanja ; Labar, Boris ; Mrsić, Mirando ; Nemet, Damir ; Bogdanić, Vinko ; Batinić, Drago ; Boban, Dubavka ; Marković-Glamočak, Mirjana ; Sučić, Mirna ; Užarević, Branka ; Stavljenić- Rukavina, Ana

Izvornik
Cancer Research Therapy Control (1064-0525) 10 (2000); 263-272

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chromosome ; acute myelogenous leukemia ; prognostic significance

Sažetak
Problem: The incidence and prognostic significance of chromosome abnormalities in patients with de-novo acute myelogenous leukemia was evaluated. Methods: From 1987. until 1995. 110 patients with de novo acute leukemia were included into the study. The majority of patients have AML-M2 (41%) or AML- M1 subtype (23%). Patients with translocation t(8 ; 21), inversion inv (16), translocation t (15 ; 17) and trisomy 21 were considered as good prognostic group while patients with trisomy 8, and changes of chromosome 5, 7 and 11 were considered as poor prognostic group. All other patients wewincluded into intermediate group. Standard G banded karyotyping was done. In some cases additional FISH was implemented. Results: Normal karyotype was found in 31 (28%) patients while abnormal karyotype was found in 62% patients. Translocations t (8 ; 21), t (15 ; 17) and t (9 ; 11) were the most frequent findings (43% of all analyzed samples). Changes of chromosome 5 and 7 were documented in 19% of all patients. According to the cytogenetics thirty (27%) patients were classified as a good prognostic group, and 43 (39%) as a poor prognosis group. Thirty-seven (34%) were classified as an intermediate group. A significantly higher (p<0.05) comlete remission rate was obtained of patients with good karyotype (81%) compared to patients with intermediate karyotype 865%) and patients with poor prognostic group (37%). The DFS probability of patients with good, intermediate and poor karyotype was 40%, 30% and 5% respectively (P=0.05). The highest probability of relapse4 is observed in patients with poor karyotype (82%). The relapse rate for patients with intermediate karyotype was 68% and for patients with good karyotype 56% (p<0.03). In multivariate analysis patients with high number of WBC at diagnosis (RR=2.7, p<0.05) older age (RR=1.4, p<0.05) and poor karyotype (RR=2.4, p<0.04) have high probability of induction treatment failure than other patients. Conclusion: Cytogenetic abnormalities were found in 72% of patients. Patients with good or intermediate karyotype had higher remission rate and better disease free survival than patients with poor karyotype.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA