Naslov
Development of mucoadhesive wafers loaded with econazole-cyclodextrin complexes for treatment of oral candidiadis

Autori
Mennini, Natascia ; Jug, Mario ; Furlanetto, Sandra ; Mura, Paola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Programme and Abstract / - Pisa : APGI & ADRITELF, 2013

Skup
3rd Conference Innovation in Drug Delivery Advances in Local Drug Delivery

Mjesto i datum
Pisa, Italija, 22.09.2013. - 25.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
econazole nitrate; buccal delivery; mucoadhesion; quality by design

Sažetak
The aim of this work was the development of an oral topical drug delivery system of econazole, endowed with mucoadhesive properties, able to assure a prolonged in situ drug release, thus allowing prevention and more efficient treatment of the Candida infection. Different kinds of hydrogels based on amidated pectins and carboxymethyl cellulose (CMC) were prepared, loaded with econazole nitrate (ECO) at 0.1% w/w, added as coground product with sulfobutylether-β-cyclodextrin and citric acid, due to its optimised dissolution properties. After freezing, the hydrogels were lyophilized, to obtain wafers for oral application. Experimental design methodologies were applied to optimize the wafer composition, maximizing its mucoadhesive properties, evaluated "ex vivo" in terms of residence time and adhesive strength to excised porcine mucosa. Drug release studies in simulated saliva were performed on the optimized formulation by using an open-compartment dissolution apparatus to maintain sink conditions. The best composition of the wafer, resulted from the analysis of the response surface plots, was: amidated pectin 7.2 % (w/w) and CMC 5.2% (w/w). The experimental values of adhesive strength (28.4  0.04 g/cm2) and residence time (88.10.1 min) given by the optimized formulation were very close to the predicted values, demonstrating the validity of the applied model. The optimized wafers showed an appropriate and controlled drug release during the observed residence time on the mucosa surface. Combination of amidated pectin and CMC, in suitable proportions, allowed preparation of mucoadhesive wafers able to form mucoadhesive hydrogels on contact with saliva and to ensure a prolonged residence time and release of the drug in situ.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA