Naslov
Tablets of Pre-Liposomes Govern In Situ Formation of Liposomes : Concept and Potential of the Novel Drug Delivery System

Autori
Vanić, Željka ; Planinšek, Odon ; Škalko-Basnet, Nataša ; Tho, Ingunn

Izvornik
European journal of pharmaceutics and biopharmaceutics (0939-6411) 88 (2014), 2; 443-445

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
spray-dried powder; lipid-based tablets; controlled release; metronidazole; nanocarrier-in-tablet

Sažetak
The purpose of this study was to develop a novel drug delivery system for challenging drugs with potential for scale-up manufacturing and controlled release of incorporated drug. Preliposomes powder containing metronidazole, lecithin and mannitol, prepared by spray-drying, was mixed with different tableting excipients (microcrystalline cellulose, lactose monohydrate, mannitol, dibasic calcium phosphate, pregelatinized starch, pectin or chitosan) and compressed into tablets. The delivery system was characterized with respect to i) dry powder characteristics, ii) mechanical tablet properties and drug release, and iii) liposomal characteristics. The pre-liposomes powder was free-flowing, and tablets of similarly high qualities as tablets made of physical mixtures were prepared with all excipients. Liposomes were formed in situ upon tablet disintegration, dissolution or erosion depending on the type of tablet excipient used. The liposomal characteristics and drug release were found to depend on the tablet excipient. The new delivery system offers a unique synergy between the ability of liposomes to solubilize poorly-soluble drugs and increased stability provided by compressed formulations. It can be adjusted for drug administration via various routes, e.g. oral, buccal and vaginal.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA