Naslov
Nasal tryptase following distilled water provocation

Autori
Bukovec, Željka ; Petek, M. ; Kalogjera, Livije ; Vagić, Davor ; Baudoin, Tomislav ; Zurak, Krešo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Abstracts of the IX Congress of International Rhinologic Society / Kern, Eugene - Washington (MD) : American Journal of Rhinology, 2000, A244-a244

Skup
Congress of International Rhinologic Society (9 ; 2000)

Mjesto i datum
Sjedinjene Američke Države, 20.09.2000. - 23.09.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
tryptase ; distilled water ; nasal provocation ; nasal lavage

Sažetak
PURPOSE: Distilled water (10 ccm per jet nebulizer during 10 minutes inhalation) nasal challenge significantly increases unilateral, but not total nasal resistance (NAR), as shown previously by the authors. Out of the research in the lower airway, mastocyte activation is involved in hyperreactive response. As the data for the nasal mucosa are inconsistent, correlation between mastocyte activation and nasal resistances is analyzed. METHODS: A group of 22 non treated hyperreactive patients (12 allergic, 10 non-allergic perennial rhinitis) were subjected to nasal challenge by inhalation of 10 ccm of distilled water. Active anterior rhinomanometry (PC 200, Atmos, BRD) was performed before and after the challenge. Data are presented as better side resistance prior to provocation, and worse side prior to provocation. Postprovocation nasal lavage with 0, 3 ccm of saline per nostril was performed (without prewashing) and try levels in lavage samples determined using the fluorometric method Unicap (Pharmacia Upjohn, Sweden). Unilateral nasal resistances were correlated with the same side nasal try levels. RESULTS: There is no significant difference between tryptase levels on more and less patent sides of the nose prior to provocation, but their correlation is significant (r=0, 98). Challenge leads to significant increase on the better patent side prior to provocation, and to significant decrease on the worse side. Correlation coeficient for the better side tryptase and postchallenge resistance is r=0, 82, and on the worse side r=0, 67. CONCLUSIONS: Although worse side tryptase is higher, the response to provocation is negative. Nasal tryptase in the allergic patients is higher than in non-allergic group. Our data suggest that mastocyte activation is involved in distilled water provocation, at least in allergic patients.

Izvorni jezik
Engleski

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