Naslov
Klinički i terapijski pristup u uznapredovaloj parkinsonovoj bolesti
(Clinical and therapeutic aspects in complicated parkinsonism)

Autori
Relja, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Neurologia Croatica / Barac, Boško ; Huber, Gerald - Zagreb : The International Neuropsychiatric Symposia in Pula, 1999, 16-17

Skup
39th International Neuropsychiatric Symposium

Mjesto i datum
Pula, Hrvatska, 02.06.1999. - 05.06.1999

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Parkinsonnova bolest; diskinezije; levodopa; DA agonisti
(Parkinson's Disease; dyskinesias; levodopa; DA agonists)

Sažetak
Parkinsonism is a clinicaol syndrome characterized by specific motor deficit: tremor, rigidity, akinesia, and postural instability. At least two of these symptoms should be present to make diagnosis. In contrast to parkinsonism Parkinson's disease (PD) is a distinct clinical and pathological entity. It is the most common form of parkinsonism and it ios also on of the most cpommon causes of neurological disability, affecting 1 percent of the population over the age of 55. Levodopa adjustment and adjunctive therapy with dopamine agonists form the major therapeutic medications strategies. Striatal DA concentration in advanced PD could also be enhanced by adding MAO-B inhibitors and COMT inhibitors (Parkinson Study Group, 1997). The weak glutamate NMDA receptor antagonist , amantadine, can be tried in patients failing levodopa therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA