Naslov
Neurophysiologic markers in laryngeal muscles indicate functional anatomy of laryngeal primary motor cortex and premotor cortex in the caudal opercular part of inferior frontal gyrus

Autori
Deletis, Vedran* ; Rogić, Maja* ; Fernandez- Conejero, Isabel* ; Gabarrós Andreau ; Jerončić, Ana

Izvornik
Clinical neuropathology (0722-5091) 125 (2014), 9; 1912-1922

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
premotor cortex ; inferior frontal gyrus ; Broca area ; primary motor cortex for laryngeal muscles ; motor speech areas ; navigated transcranial magnetic stimulation ; electrical stimulation of motor speech areas ; neurophysiologic markers

Sažetak
Objective was to identify neurophysiologic markers generated by primary motor and premotor cortex for laryngeal muscles, recorded from laryngeal muscle. Ten right handed healthy subjects underwent nTMS and eighteen patients underwent DCS over the left hemisphere, while recording neurophysiologic markers ; short latency response (SLR) and long latency response (LLR) from cricothyroid muscle. Both healthy subjects and patients were engaged in the visual object naming task. In healthy subjects the stimulation was time locked at 10-300 ms after picture presentation while in the patients it was at zero time. The latency of SLR in healthy subjects was 12.66±1.09 ms and in patients 12.67±1.23 ms. The latency of LLR in healthy subjects was 58.5 ± 5.9 ms, while in patients 54.25±3.69 ms. SLR elicited by stimulation of M1 for laryngeal muscles corresponded to induced dysarthria, while LLR elicited by stimulation of the premotor cortex in the caudal opercular part of inferior frontal gyrus, recorded from laryngeal muscle corresponded to speech arrest in patients and speech arrest and/or language disturbances in healthy subjects. In both groups, SLR indicated location of M1 for laryngeal muscles, and LLR location of premotor cortex in the caudal opercular part of inferior frontal gyrus, recorded from laryngeal muscle, while stimulation of these areas in the dominant hemisphere induced transient speech disruptions. Significance Described methodology can be used in preoperative mapping, and it is expected to facilitate surgical planning and intraoperative mapping preserving these areas from injuries. Key

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
*authors equally contributed.

POVEZANOST RADA