Naslov
Molecular epidemiology of rotavirus in Central and Southeastern Europe

Autori
Tcheremenskaia, Olga ; Marucci, Gianluca ; De Petris, Simona ; Ruggeri, Franco Maria ; Dovecar, Darja ; Ljubin-Sternak, Sunčanica ; Matayasova, Irena ; Dhimolea, Majlinda Kota ; Mladenova, Zornitsa ; Fiore, Lucia ; and rotavirus study group

Izvornik
Journal of clinical microbiology (0095-1137) 45 (2007), 7; 2197-2204

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rotavirus; genotypes

Sažetak
A surveillance network was implemented by Istituto di Sanita of Rome in collaboration with laboratories of virology in Czech Republic, Slovenia, Croatia, Albania, and Bulgaria. About 1, 500 rotavirus-positive stool samples were collected from children with severe gastroenteritis admitted to hospitals or outpatient wards between 2004 and 2006. The G and P genotypes were determined b< reverse transcription-nested PCR. Significant differences were found in the geographical distribution of rotavirus genotypes between countries participating in the study. The prevalence of “common” G/P combinations, G1P[8], G3P[8], G4P[8], and G2P[4], ranged between 50 and 85%. The G9 genotype, which is emerging worldwide, was identified in 2 to 35% of all samples depending on the country. Unusual combinations, such as G1 or G4 associated with P[4] or G2 with P[8], which may have arisen by reassortment between human strains, were found in samples from 3 to 20% of patients. The uncommon genotypes G8P[8] and G10P[6], which may have an animal origin, were also identified. Double infections with two rotavirus strains were observed in between1.7 and 14% of cases studied. Our findings might implicate challenges for rotavirus vaccine implementation in a wide geographic area of the Balkans and Central-Eastern Europe and underscore the importance of extensive strain surveillance for success in vaccine development.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA