Naslov
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
(Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.)

Autori
Bønnelykke, K. : ... ; Bukvić K., Blaženka ; ... ; Baltić, Svetlana ; ... ; Blekić, Mario ; ... ; Čustović, Adnan ; ... ; Henderson, John A.

Izvornik
Nature genetics (1061-4036) 45 (2013), 8; 902-906

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
atopy; allergic disease; genetic polymorphisms

Sažetak
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5, 789 affected individuals and 10, 056 controls and followed up the top SNP at each of 26 loci in 6, 114 affected individuals and 9, 920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.

Izvorni jezik
Engleski

Napomena
Australian Asthma Genetics Consortium (AAGC) ; EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium.

POVEZANOST RADA