Naslov
Glucose reduces alloxan induced alterations of nociception

Autori
Šalković-Petrišić, Melita ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Fundamental&Clinical Pharmacology 1999; vol. 13, Suppl 1 / Guidicelli, Jean-Francois - Pariz : Elsevier, 1999

Skup
2nd European Congress of Pharmacology

Mjesto i datum
Budimpešta, Mađarska, 03.07.1999. - 09.07.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
alloxan; glucose; nociception

Sažetak
According to literature data, alloxan-induced betacytotoxic effects can be prevented by prior glucose administration. We investigated the effects of peripheral (intraperitoneal/ip) and central (intracerebroventricular/icv) 0.1 M and 1 M glucose-15 min pretreatment on centrally (icv) applied alloxan (1000 ug/kg)-induced alterations of nociception, dtetermined by the 'hot-plate' and 'tail immersion' tests. Alloxan icv treatment alone induced bradual increase (</= 100% over control) of pain treshold in both tests in the course of a 3 week posttreatment period. Similar increment of pain treshold was induced by a glucose (ip/icv) treatment alone, as well. Glucose pretreatment, in general, reduced alloxan induced increase of pain treshold in both tests. However, the effect was more consistent, pronounced with higher glucose dose (in the hot test plate even reversed to control values) and could be seen as early as 1 week following glucose icv (vs. 3 weeks following glucose ip pretreatment). It seems that glucose 15 min-pretreatment reduces alloxan icv-induced alterations of pain treshold, with glucose icv preptreatment being more successful than glucose ip pretreatment.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA