Pregled bibliografske jedinice broj: 68053
Klozapin u terapiji psihoze u uznapredovaloj parkinsonovoj bolesti
Klozapin u terapiji psihoze u uznapredovaloj parkinsonovoj bolesti // Fundamental & Clinical Pharmacology / Giudicelli, Jean-Francois (ur.).
Pariz: Elsevier, 1999. str. 390-390 (poster, međunarodna recenzija, sažetak, ostalo)
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Naslov
Klozapin u terapiji psihoze u uznapredovaloj parkinsonovoj bolesti
(Clozapine in the treatment of psychosis in advanced PD)
Autori
Relja, Maja
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo
Izvornik
Fundamental & Clinical Pharmacology
/ Giudicelli, Jean-Francois - Pariz : Elsevier, 1999, 390-390
Skup
2nd European Congress Of Pharmacology
Mjesto i datum
Budimpešta, Mađarska, 03.07.1999. - 07.07.1999
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Klozapin; Parkinsonova bolest; Psihoza
(Clozapine; Parkinson's Disease; Psychosis)
Sažetak
Chronic levodopa treatment in PD is often complicated by halucinations and delusions. Clozapine, an atypical neuroleptic, possesses a relatively high affinity for the dopamine D4 receptors. It has been reported that clozapine treatment improves psychosis in PD patients. However, contradictory resuzlts have been reported about CBC changes during cloizapine administration. Here we report nine PD patients (age range 57-73 years, disease duration 5-13 years, H&Y stage 2-4) who developed hallucinations and delusions. Patients were commenced on 25 mg clozapine (Leponex) at night and the dose titrated to a maximum of 75 mg until the symptoms were abolished. Our preliminary open study indicated that clozapine shouls be considered for the treatment of psychosis in selected PD patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
