Naslov
Chapter 7: Aristolochic Acid Nephropathy: An Environmental and Iatrogenic Disease

Autori
Grollman, Arthur P. ; Scarborough, John ; Jelaković, Bojan

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Advances in Molecular Toxicology, Volume 3

Urednik/ci
James C. Fishbein

Izdavač
Elsevier

Godina
2009

Raspon stranica
221-227

ISBN
978-0-444-53357-9

Ključne riječi
aristolochic acid, Chinese herb nephropathy, endemic (Balkan) nephropathy, urothelial (transitional cell) cancer

Sažetak
This chapter reviews the molecular and clinical toxicology of aristolochic acid (AA), nephrotoxic chemical carcinogen. Recently, AA, a principal component of all Aristolochia sp., is shown to be the toxin responsible for the clinical syndromes known as Chinese herb nephropathy (CHN) and endemic (Balkan) nephropathy (EN). The epidemiology and pathophysiology of CHN and EN are reviewed extensively and the association of these diseases with human cancer is the subject of several comprehensive reports. Both disorders are associated with a high incidence of urothelial (transitional cell) cancer and appear to constitute a single disease entity, designated aristolochic acid nephropathy (AAN). The dramatic revelation that AA is a powerful nephrotoxin and carcinogen for humans drew attention to the worldwide distribution and extensive use of Aristolochia sp. as herbal remedies. The subsequent reports described almost 200 patients outside of Belgium in whom chronic renal failure followed ingestion of Aristolochia herbs. In addition based on the traditional use of Aristolochia in herbal remedies, the chapter posits that AAN represents a long-overlooked iatrogenic disease and an international public health problem of considerable magnitude.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

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