Naslov
Endemic (Balkan) Nephropathy: A disease caused by aristolochic acid.

Autori
Jelaković, Bojan ; Dika, Živka ; Grollman, Arthur P.

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Environmental and Food Safety and Security for South-East Europe and Ukraine

Urednik/ci
Vitale Ksenija

Izdavač
Springer

Godina
2012

Raspon stranica
219-227

ISBN
978-94-007-2952-0

Ključne riječi
Endemic (Balkan) nephropathy, transitional urothelial cell carcinoma of the upper urinary tract, environmental toxin

Sažetak
Endemic (Balkan) nephropathy (EN) is a devastating chronic renal disease, affecting residents of rural villages situated near tributaries of the Danube river in Croatia, Bosnia and Herzegovina, Serbia, Bulgaria and Romania. The disease affects at least 25, 000 men and women, while another 75, 000 are estimated to be at risk. The prevalence of confirmed EN cases in the endemic regions of Croatia has fluctuated between 2% and 10% of the village population. Significant epidemiologic features of EN include its presence only in certain villages ; a familial pattern of disease ; occurrence in adults and never in children under 15 years of age ; restriction to rural farming populations ; and strong association (∼50%) with transitional urothelial cell carcinoma of the upper urinary tract. This epidemiologic evidence strongly suggests that an environmental toxin is involved in the etiology of EN and its associated cancers.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA