Naslov
Liposomi kao nosači lijekova: Metode priprave
(Liposomes as drug carriers: Preparation methods)

Autori
Vanić, Željka

Izvornik
Farmaceutski glasnik : glasilo Hrvatskog farmaceutskog društva (0014-8202) 68 (2012); 457-466

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
Liposomi; Metode priprave
(Liposomes; Preparation methods)

Sažetak
The key point to grasp in considering the manufacture of liposomes is that phospholipid membranes form spontaneously as a result of unfavourable interactions between phospholipids and water. Thus the emphasis in making liposomes is not towards assembling the membranes (which happens on its own accord), but towards getting the membranes to form vesicles of the right size and structure, and to entrap drugs with high efficiency and in such a way that they do not leak out of the liposome once formed. All methods of making liposomes involve three or four basic stages: drying down of lipids from organic solvents, dispersion of the lipids in aqueous media, purification of the resultant liposomes and analysis of the final product. The main difference between the various methods of manufacture is in the way in which the membrane components are dispersed in aqueous media, before being allowed to coalesce in the form of bilayer sheets. The methods are classified according to three basic modes of dispersion: physical dispersion, two-phase dispersion and detergent solubilization.

Izvorni jezik
Hrvatski

Znanstvena područja
Farmacija

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