Naslov
Characterization and in vitro evaluation of deformable liposomes for vaginal delivery

Autori
Vanić, Željka ; Škalko-Basnet, nataša ; Hurler, Julia ; Ferderber, Kristina ; Golja Gašparović, Petra ; Filipović-Grčić, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
The 9th Central European Symposium on Pharmaceutical Technology with focus on Nanopharmaceuticals and Nanomedicine

Mjesto i datum
Dubrovnik, Hrvatska, 20.09.2012. - 22.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Deformable liposomes; Metronidazole; Clotrimazole; Bioadhesive gel; Vaginal delivery

Sažetak
Deformable liposomes composed of egg phosphatidylcholine (85%) and sodium deoxycholate (15%) containing metronidazole or clotrimazole were prepared by the modified ethanol injection method. Physicochemical characterization of various liposomes was based on determining the size, the polidispersity, zeta potential and entrapment efficiency of drugs. The optimal formulations of deformable vesicles containing either metronidazole or clotrimazole, were incorporated in hydrogel composed of 1% Carbopol 974P NF. In vitro release studies of the drugs entrapped in liposomes and incorporated in gels performed in the buffer pH 4.5 and vaginal fluid simulant pH 4.5 have demonstrated sustained release of both, clotrimazole and metronidazole. Components of vaginal fluid and lower pH (pH 4.5) influenced the stability of liposomes, as compared to control study (pH 6). Regarding the physical properties of liposomal gels, different rheological measurements and mucoadhesiveness on vaginal tissue were performed and will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA