Naslov
Comorbidity-associated hospitalizations in IBD patients in tertiary refferal center

Autori
Prijic, Radovan ; Crncevic Urek, Marija ; Cukovic- Cavka, Silvija ; Brinar, Marko ; Turk, Niksa ; Krznaric, Zeljko ; Vucelic, Boris

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Falk Symposium London 2013. Abstract book / - , 2013

Skup
FALK Symposium

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
inflammatory bowel disease (IBD); Crohn's disease; ulcerative colitis; comorbidity-associated hospitalizations

Sažetak
Introduction: Inflammatory bowel disease (IBD) patients tend to have higher incidence of certain diseases in comparison to the general population. These comorbidites can be the cause of reccuring hospitalizations among IBD patients. The aim of this retrospective study was to analyze admission of IBD patients to hospital due to comorbidities. Methods: Hospital database records were searched for comorbidity-associated and IBD-associated hospitalizations during the period of two years (January 2011-January 2013). Crohn's disease (CD) patients were divided into groups according to the age at diagnosis, disease location and behaviour using Montreal classification (L1-4, B1-3). Ulcerative colitis (UC) patients were divided using the same classification. Logistic regression, Fisher's exact and Chi-squared tests were used to identify factors influencing comorbidity-related hospitalizations. Results: Our study included 257 IBD patients with a total of 506 hospitalizations. Diagnosis of CD was established for 188 patients (73.15%, median age at diagnosis 18 years), while 69 patients were diagnosed with UC (26, 85%, median age at diagnosis 32 years). Slight predominance of female patients (N=140, 54.47%) was obsereved. Hospitalization due to different comorbidities comprised 16.01% (81/506) of total admissions. Statistical logistic regression model showed ileal disease (L1) CD patients are less likely to be hospitalized for comorbidities of any kind. Also, we found higher likelihood of comorbidity- associated hospitalizations in CD patients assigned to the higher age at diagnosis-groups. UC patients showed no statistically significant difference between groups with regards to comorbidity-related hospital admission. Discussion / Conclusion: CD patient's age at the time of diagnosis is a significant factor reflecting the rate of comorbidity-associated hospitalizations. Ileal form of CD is associated with lower probability of comorbidity-related hospital admissions. It could be hypothesized that this difference is a result of milder disease course and less potent therapy regimens. These findings require a prospective study on a larger cohort of patients in order to confirm and further elucidate the background of our results.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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