Naslov
Ribosomal proteins and p53 regulation

Autori
Volarevic, Sinisa

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEBS 3+ Meeting, From molecules to life and back, Book of Abstracts / - , 2012

Skup
FEBS 3+ Meeting, From molecules to life and back

Mjesto i datum
Opatija, Hrvatska, 13.06.2012. - 16.06.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Ribosomal proteins; p53; DNA damage; nucleolus

Sažetak
The exposure of cells to various DNA-damaging stressors activates p53 to preserve cellular and genetic stability, preventing tumor development in mice and humans. The critical role of p53 in tumor suppression is supported by the observation that approximately 50% of all human cancers have mutations within this gene. Although it was largely accepted that common to all p53-activating stresses is DNA damage, research over the last decade has shown that disruption of ribosome biogenesis activates p53 via binding of several ribosomal proteins (RP) to Mdm2 and inhibition of its E3 ubiquitin ligase activity against p53 independently of DNA damage. The observation that many DNA-damaging stressors inhibit ribosome biogenesis and consequently disrupt nucleoli suggests that signalling pathways involved in p53 activation by DNA damage and defects in ribosome biogenesis might share common components. However, despite huge research efforts in this field, the molecular mechanisms underlying transduction of the p53-activating signals by specific RPs remain largely obscure. Recently, we demonstrated the key role for RPL5 and RPL11 but not other previously suggested “p53- activating” RPs in p53 activation by various stressors and provided a novel mechanistic insight into this regulation.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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